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KMID : 1161420110140070840
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Journal of Medicinal Food
2011 Volume.14 No. 7 p.840 ~ p.846
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Identification of Antioxidant and Antimicrobial Compounds of Lippia Species by Bioautography
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Fabri Rodrigo Luiz
Nogueira Mauro Silva
dos Reis Moreira Jussara
Bouzada Maria Lucia Morcef
Scio Elita
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Abstract
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The methanolic extracts of the leaves of Lippia species (L. pseudo-thea, L. hermannioides, L. alba, L. rubella, and L. sidoides) were tested for their antibacterial, antifungal, and antioxidant activity. Cytotoxicity was determined by using brine shrimp lethality bioassay. Phytochemical screening was also performed. The extracts showed a minimum inhibitory concentration (MIC) ranging from 78 to 5000?μg/mL for antibacterial activity against at least 2 species of bacteria, although none was active against Escherichia coli. Antifungal activity was found only for L. pseudo-thea (MIC, 625?μg/mL for Candida albicans) and L. sidoides (MIC, 625?μg/mL for both C. albicans and C. neoformans). The bioautography showed that flavonoids and coumarins are responsible for the antioxidant activity of the extracts and that the antimicrobial properties are due to flavonoids and terpenoids. The cytotoxic activity was stronger for L rubella extract. To our knowledge, this is the first report of the biological and chemical constituents of L. pseudo-thea, L. hermannioides, and L. rubella.
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KEYWORD
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antimicrobial, antioxidant, bioautography, Lippia, polyphenols
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